I think the general response is that all atheists are either a) not looking for God correctly (which kind of ignores the argument, but what other response could they give?) or b) all unreasoning, arrogant people and deserve to go to hell, bwahahahahahaa.
(more or less).
It doesn't really work on a Christian or other such believer as they believe there is already insurmountable evidence ('design', 'creation'...). Of course, that begs the question of why anyone can disbelieve, even the most arrogant, if the evidence is truly divinely insurmountable. Chances are, in response to that, you'll hear some twisted hybrid of 'free will' and 'take it on faith!'.
Disproving the Bible in a signature:
Revelations 22:18 ...If any man shall add unto these things, God shall add unto him the plagues that are written in this book
Revelations 23:1 And God said 'hi'.
(I'm still fine)